Title

Porphyrin Synthesis through Tripyrrins: An Alternate Approach

Document Type

Article

Publication Date

1-1-1983

Abstract

A new route for synthesis of unsymmetrically substituted porphyrins is described. The route follows the earlier approach through pyrromethanes, tripyrrin hydrobromides, and a,c-biladiene dihydrobromides, except that the pyrromethane intermediate is elongated in an initially “clockwise” direction to give a benzyl tripyrrincarboxylate. Various advantages over the tert-butyl tripyrrincarboxylates used in the earlier method (Scheme I) are discussed. The new route is demonstrated in the syntheses of five pure porphyrins required for other current studies. © 1983, American Chemical Society. All rights reserved.

Publication Source (Journal or Book title)

Journal of Organic Chemistry

First Page

4302

Last Page

4306

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