Functional reconstitution of rat liver cytochrome P-450 with mesohemin
After allylisopropylacetamide-mediated "suicide" destruction of their prosthetic heme moieties, certain rat liver cytochrome P-450 isozymes can be effectively reconstituted by addition of exogenous hemin in vitro. We now report that two of these isozymes will equally accept mesohemin, a 2,4-diethyl heme-analog and result in a "meso-hemoprotein" with altered spectral but not functional characteristics. © 1984.
Publication Source (Journal or Book title)
Biochemical and Biophysical Research Communications
Bornheim, L., Correia, M., & Smith, K. (1984). Functional reconstitution of rat liver cytochrome P-450 with mesohemin. Biochemical and Biophysical Research Communications, 121 (1), 95-101. https://doi.org/10.1016/0006-291X(84)90692-2