Title

Functional reconstitution of rat liver cytochrome P-450 with mesohemin

Document Type

Article

Publication Date

5-31-1984

Abstract

After allylisopropylacetamide-mediated "suicide" destruction of their prosthetic heme moieties, certain rat liver cytochrome P-450 isozymes can be effectively reconstituted by addition of exogenous hemin in vitro. We now report that two of these isozymes will equally accept mesohemin, a 2,4-diethyl heme-analog and result in a "meso-hemoprotein" with altered spectral but not functional characteristics. © 1984.

Publication Source (Journal or Book title)

Biochemical and Biophysical Research Communications

First Page

95

Last Page

101

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