Title

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization

Document Type

Article

Publication Date

1-1-1988

Abstract

Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.

Publication Source (Journal or Book title)

Journal of Clinical Investigation

First Page

1134

Last Page

1143

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