Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages
The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II® are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo. © 1990.
Publication Source (Journal or Book title)
Pandey, R., Shiau, F., Medforth, C., Dougherty, T., & Smith, K. (1990). Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages. Tetrahedron Letters, 31 (51), 7399-7402. https://doi.org/10.1016/S0040-4039(00)88499-3