Title

Isomeric Monoacetylmono(1-hydroxyethyl)deuteroporphyrins: Syntheses, Characterization, and Use for the Syntheses of Regioselectively Methyl-and Vinyl-Deuterated Hemins

Document Type

Article

Publication Date

1-1-1990

Abstract

Treatment of hematoporphyrin IX dimethyl ester (7) with tetrapropylammonium perruthenate (Prn4N)(Ru04) and N-methylmorpholine N-oxide affords a high yield of the separable monoacetylmono(1-hydroxyethyl)-deuteroporphyrin isomers 5 and 6. Proton NMR NOE experiments and chemical transformations involving specific individual deuteration at the 1- and 3-methyls and 2- and 4-vinyls are used to characterize the isomers. © 1990, American Chemical Society. All rights reserved.

Publication Source (Journal or Book title)

Journal of Organic Chemistry

First Page

2190

Last Page

2195

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