Title
Isomeric Monoacetylmono(1-hydroxyethyl)deuteroporphyrins: Syntheses, Characterization, and Use for the Syntheses of Regioselectively Methyl-and Vinyl-Deuterated Hemins
Document Type
Article
Publication Date
1-1-1990
Abstract
Treatment of hematoporphyrin IX dimethyl ester (7) with tetrapropylammonium perruthenate (Prn4N)(Ru04) and N-methylmorpholine N-oxide affords a high yield of the separable monoacetylmono(1-hydroxyethyl)-deuteroporphyrin isomers 5 and 6. Proton NMR NOE experiments and chemical transformations involving specific individual deuteration at the 1- and 3-methyls and 2- and 4-vinyls are used to characterize the isomers. © 1990, American Chemical Society. All rights reserved.
Publication Source (Journal or Book title)
Journal of Organic Chemistry
First Page
2190
Last Page
2195
Recommended Citation
Shiau, F., Smith, K., Pandey, R., Dougherty, T., & Ramaprasad, S. (1990). Isomeric Monoacetylmono(1-hydroxyethyl)deuteroporphyrins: Syntheses, Characterization, and Use for the Syntheses of Regioselectively Methyl-and Vinyl-Deuterated Hemins. Journal of Organic Chemistry, 55 (7), 2190-2195. https://doi.org/10.1021/jo00294a039