Biosynthetic Studies of Substituent Homologation in Bacteriochlorophylls c and d
Administration of carbon-13 and carbon-14 labeled glutamate, glycine, and methionine to Chlorobium vibrioforme forma thiosulfatophilum strain D have demonstrated operation of the C5 and C1 metabolic pathways in bacteriochlorophyll c and bacteriochlorophyll d biosynthesis in this organism, with glutamate providing the δ-aminolevulinic acid for macrocycle synthesis and glycine providing the source of the extra homologation at the 4-, 5-, and δ-positions (via S-adenosylmethionine). Further evidence showing that the bacteria appear to adjust the homologue composition of their antenna bacteriochlorophylls in response to varying growth conditions is presented. Timing of these changes within a single culture is consistent with a light adaptation mechanism, which predicts that degree of alkylation is directly proportional to light intensity in the culture; other factors influencing pigment composition during the lifespan of a single culture may also be operating, and these are discussed. © 1990, American Chemical Society. All rights reserved.
Publication Source (Journal or Book title)
Huster, M., & Smith, K. (1990). Biosynthetic Studies of Substituent Homologation in Bacteriochlorophylls c and d. Biochemistry, 29 (18), 4348-4355. https://doi.org/10.1021/bi00470a013