Title

Syntheses of cationic porphyrins and chlorins

Document Type

Article

Publication Date

12-1-1991

Abstract

Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.

Publication Source (Journal or Book title)

Journal of the Chemical Society, Chemical Communications

First Page

1637

Last Page

1638

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