Syntheses of cationic porphyrins and chlorins
Treatment of vinyl-chlorins 2,4,5 and -porphyrins 8 with N,N-dimethylmethyleneammonium iodide affords the corresponding vinyl-extended Mannich adducts 3,6,7,9; with deuteroporphyrin IX dimethyl ester 10 the product is the bis-Mannich base 11; quaternization of the products is readily accomplished with methyl iodide to afford a general method for synthesis of water-soluble cationic sensitizers for use in photodynamic therapy.
Publication Source (Journal or Book title)
Journal of the Chemical Society, Chemical Communications
Pandey, R., Smith, N., Shiau, F., Dougherty, T., & Smith, K. (1991). Syntheses of cationic porphyrins and chlorins. Journal of the Chemical Society, Chemical Communications (22), 1637-1638. https://doi.org/10.1039/C39910001637