New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy
An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study. © 1992.
Publication Source (Journal or Book title)
Bioorganic and Medicinal Chemistry Letters
Meunier, I., Pandey, R., Walker, M., Senge, M., Dougherty, T., & Smith, K. (1992). New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy. Bioorganic and Medicinal Chemistry Letters, 2 (12), 1575-1580. https://doi.org/10.1016/S0960-894X(00)80433-3