Title

Structure/activity relationships among photosensitizers related to pheophorbides and bacteriopheophorbides

Document Type

Article

Publication Date

1-1-1992

Abstract

A series of long wavelength absorbing photosensitizers related to pheophorbide-a, pyropheophorbide-a, bacteriopheophorbide-a and chlorin-e6 were synthesized and evaluated for their comparative in vivo tumorcidal activity and skin phototoxicity vis-a-vis Photofrin®. Structure/function relationships are discussed. All new photosensitizers were found to have high production of 1O2 and reduced skin phototoxicity compared to Photofrin®. © 1992.

Publication Source (Journal or Book title)

Bioorganic and Medicinal Chemistry Letters

First Page

491

Last Page

496

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