Improved photosensitizers for photodynamic therapy
In order to evaluate the effect of substituents in photosensitizing activity, a series of long wavelength absorbing photosensitizers related to pyropheophorbides, bacteriopheophorbides, and benzoporphyrin derivatives were synthesized. Pheophorbide dimers, covalently joining two molecules of pyropheophorbide-a and bacteriopheophorbide-a with lysine as a cross-link were also prepared. The syntheses and spectroscopic properties of these compounds are discussed. Some of these compounds were tested for in vivo photosensitizing activity vis-a-vis Photofrin IITM, using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. The preliminary in vivo results suggest that replacement of substituents at peripheral positions of the macrocycles causes a significant difference in photosensitizing efficacy.
Publication Source (Journal or Book title)
Proceedings of SPIE - The International Society for Optical Engineering
Pandey, R., Shiau, F., Meunier, I., Ramaprasad, S., Sumlin, A., Dougherty, T., & Smith, K. (1992). Improved photosensitizers for photodynamic therapy. Proceedings of SPIE - The International Society for Optical Engineering, 1645, 264-273. Retrieved from https://digitalcommons.lsu.edu/chemistry_pubs/1865