Title

Pharmaceutical analysis for environmental samples: Individual and simultaneous determination of ciprofloxacin, ofloxacin and norfloxacin using an HPLC with fluorescence and UV detection with a wetland soil matrix

Document Type

Article

Publication Date

11-26-2009

Abstract

Two HPLC methods were developed for individual and simultaneous determination of ciprofloxacin, norfloxacin and ofloxacin for use in laboratory experiments producing large numbers of samples (100 s to 1000 s). Individual compound detection produced retention times between 1.5 and 2 min and simultaneous detection between 6.5 to 8 min. The methods are compatible with complex geomatrices, e.g. a wetland soil. These methods provide 1) detection limits in the low parts per-billion range; 2) decrease in retention times of 5-10 times for single compounds, and up to 2 times for simultaneous detection over published methods; and 3) require no solid phase extraction. © Taylor & Francis Group, LLC.

Publication Source (Journal or Book title)

Analytical Letters

First Page

2937

Last Page

2950

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