Title
Chlorophyll-a derivatives in photodynamic therapy: Effect of position of heptyl ether side-chains on in vivo photosensitizing activity
Document Type
Article
Publication Date
1-9-1996
Abstract
Syntheses and comparative in vivo photosensitizing efficacy of a series of chlorophyll-a derivatives with (1-heptyloxyethyl) substituents at various positions are discussed. Compared with Photofrin®, the n-heptyl ether analogues showed better in vivo sensitizing activity (DBA/2 mice transplanted with SMT/F tumors) as well as reduced skin phototoxicity. The Vilsmeier formylation of copper(II) methyl mesopyropheophorbide-a 11 did not produce the expected meso-formyl derivative 12, but instead gave the α,β-unsaturated chloroformyl analogue 13 as the major product.
Publication Source (Journal or Book title)
Bioorganic and Medicinal Chemistry Letters
First Page
105
Last Page
110
Recommended Citation
Pandey, R., Constantine, S., Goff, D., Kozyrev, A., Dougherty, T., & Smith, K. (1996). Chlorophyll-a derivatives in photodynamic therapy: Effect of position of heptyl ether side-chains on in vivo photosensitizing activity. Bioorganic and Medicinal Chemistry Letters, 6 (1), 105-110. https://doi.org/10.1016/0960-894X(95)00568-E