A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes
Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN-Cu(OTf)2 produced unexpected 103-trimethylsiloxyl and 103-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 103-position of the exocyclic benzene ring to form a novel benzochlorin.
Publication Source (Journal or Book title)
Li, G., Mehta, R., Srikrishnan, T., Nurco, D., Tabaczynski, W., Alderfer, J., Smith, K., Dougherty, T., & Pandey, R. (2002). A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes. Chemical Communications, 11, 1172-1173. https://doi.org/10.1039/b202280j