Formation of chlorins and meso-substituted porphyrins through intramolecular nitrogen-carbon migration of N-substituted porphyrins
A series of N-substituted porphyrins were synthesized either by direct alkylation of the symmetrical porphyrins or from the unsymmetrical porphyrins obtained via MacDonald's procedure using the appropriate N-substituted dipyrromethanes. Depending upon the nature of the peripheral substitutions in the porphyrin system, the nickeI(II)-promoted rearrangement of these compounds gave either meso-substituted or unsubstituted Ni(II)porphyrins or chlorins. The chlorins and meso-substituted porphyrins were formed via the intramolecular migration of the N-substituent to carbon. This approach provides easy access for the synthesis of chlorins and the meso-substituted porphyrins, which are otherwise difficult to synthesize. Copyright © 2008 Society of Porphyrins & Phthalocyanines.
Publication Source (Journal or Book title)
Journal of Porphyrins and Phthalocyanines
Pandey, R., Zheng, X., Dobhal, M., & Smith, K. (2008). Formation of chlorins and meso-substituted porphyrins through intramolecular nitrogen-carbon migration of N-substituted porphyrins. Journal of Porphyrins and Phthalocyanines, 12 (2), 131-141. https://doi.org/10.1142/S1088424608000170