Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains
In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom chain in 1) were synthesized from monopyrrole precursors.
Publication Source (Journal or Book title)
Holmes, R., Lu, J., Mwakwari, C., & Smith, K. (2010). Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains. Arkivoc, 2010 (5), 5-16. https://doi.org/10.3998/ark.5550190.0011.502