Syntheses, properties and cellular studies of metallo-isoporphyrins
b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature. © 2011 World Scientific Publishing Company.
Publication Source (Journal or Book title)
Journal of Porphyrins and Phthalocyanines
Mwakwari, S., Wang, H., Jensen, T., Vicente, M., & Smith, K. (2011). Syntheses, properties and cellular studies of metallo-isoporphyrins. Journal of Porphyrins and Phthalocyanines, 15 (9-10), 918-929. https://doi.org/10.1142/S108842461100380X