Lignin-Graft-Poly(lactic- co-glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis
Copyright © 2020 American Chemical Society. A lignin-graft-poly(lactic-co-glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). 1H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100-200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (-48 to -60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core-shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.
Publication Source (Journal or Book title)
Astete, C., De Mel, J., Gupta, S., Noh, Y., Bleuel, M., Schneider, G., & Sabliov, C. (2020). Lignin-Graft-Poly(lactic- co-glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis. ACS Omega, 5 (17), 9892-9902. https://doi.org/10.1021/acsomega.0c00168