Synthesis, Structure, and Stability of the Zinc Complex of the Dimethyl Ester of meso-2,3-Dimercaptosuccinic Acid
The dimethyl ester of meso-2,3-dimercaptosuccinic acid (meso-DiMeDMSA) reacts with Zn2+ ions to form protonated and polynuclear complexes. The species [Zn2L3H]- and [Zn2L3]2- are formed at pH values between 3 and 6.5 and have overall formation constants of 1037.53 and 1032.52, respectively, whereas the mononuclear complex [ZnL2]2- is formed at physiological pH and has a formation constant of 1018.06. The mononuclear complex was synthesized and isolated as an ion association complex with the tetramethylammonium ion, [(Me)4N]2[Zn(DiMeDMSA)2], and its structure in solution was determined by low-temperature and 13C NMR spectroscopy. In this structure the Zn2+ ion is tetrahedrally coordinated to four thiolate groups from two meso-DiMeDMSA molecules. © 1992, American Chemical Society. All rights reserved.
Publication Source (Journal or Book title)
Chemical Research in Toxicology
Rivera, M., & Fernando, Q. (1992). Synthesis, Structure, and Stability of the Zinc Complex of the Dimethyl Ester of meso-2,3-Dimercaptosuccinic Acid. Chemical Research in Toxicology, 5 (1), 142-147. https://doi.org/10.1021/tx00025a024