Title

Synthesis, Structure, and Stability of the Zinc Complex of the Dimethyl Ester of meso-2,3-Dimercaptosuccinic Acid

Document Type

Article

Publication Date

1-1-1992

Abstract

The dimethyl ester of meso-2,3-dimercaptosuccinic acid (meso-DiMeDMSA) reacts with Zn2+ ions to form protonated and polynuclear complexes. The species [Zn2L3H]- and [Zn2L3]2- are formed at pH values between 3 and 6.5 and have overall formation constants of 1037.53 and 1032.52, respectively, whereas the mononuclear complex [ZnL2]2- is formed at physiological pH and has a formation constant of 1018.06. The mononuclear complex was synthesized and isolated as an ion association complex with the tetramethylammonium ion, [(Me)4N]2[Zn(DiMeDMSA)2], and its structure in solution was determined by low-temperature and 13C NMR spectroscopy. In this structure the Zn2+ ion is tetrahedrally coordinated to four thiolate groups from two meso-DiMeDMSA molecules. © 1992, American Chemical Society. All rights reserved.

Publication Source (Journal or Book title)

Chemical Research in Toxicology

First Page

142

Last Page

147

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