Title

A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Document Type

Article

Publication Date

5-19-1992

Abstract

meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine. © 1992.

Publication Source (Journal or Book title)

Tetrahedron Letters

First Page

2961

Last Page

2964

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