Title
A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.
Document Type
Article
Publication Date
5-19-1992
Abstract
meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine. © 1992.
Publication Source (Journal or Book title)
Tetrahedron Letters
First Page
2961
Last Page
2964
Recommended Citation
Polt, R., Li, Y., Fernando, Q., & Rivera, M. (1992). A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.. Tetrahedron Letters, 33 (21), 2961-2964. https://doi.org/10.1016/S0040-4039(00)79572-4