Title

Synthesis of [1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acid

Document Type

Article

Publication Date

8-1-1997

Abstract

[1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acids (δ-ALAs) have been prepared by a four-step sequence. [1,2-13C]-ethyl bromoacetate was used to introduce the labels in the 1,2-labeled δ-ALA while [2-13C]-ethyl bromoacetate and [5-13C]-Meldrum's acid were used to introduce the labels in the 2,3-labeled derivative. These amino acid building blocks can be used to prepare heme-containing proteins with labeled hemes according to a previously reported biosynthetic method.

Publication Source (Journal or Book title)

Journal of Labelled Compounds and Radiopharmaceuticals

First Page

669

Last Page

675

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