Title
Synthesis of [1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acid
Document Type
Article
Publication Date
8-1-1997
Abstract
[1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acids (δ-ALAs) have been prepared by a four-step sequence. [1,2-13C]-ethyl bromoacetate was used to introduce the labels in the 1,2-labeled δ-ALA while [2-13C]-ethyl bromoacetate and [5-13C]-Meldrum's acid were used to introduce the labels in the 2,3-labeled derivative. These amino acid building blocks can be used to prepare heme-containing proteins with labeled hemes according to a previously reported biosynthetic method.
Publication Source (Journal or Book title)
Journal of Labelled Compounds and Radiopharmaceuticals
First Page
669
Last Page
675
Recommended Citation
Bunce, R., Schilling, C., & Rivera, M. (1997). Synthesis of [1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acid. Journal of Labelled Compounds and Radiopharmaceuticals, 39 (8), 669-675. https://doi.org/10.1002/(SICI)1099-1344(199708)39:8<669::AID-JLCR17>3.0.CO;2-B