Synthesis and biological evaluation of manzamine analogues
The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A. © 2006 American Chemical Society.
Publication Source (Journal or Book title)
Winkler, J., Londregan, A., Ragains, J., & Hamann, M. (2006). Synthesis and biological evaluation of manzamine analogues. Organic Letters, 8 (15), 3407-3409. https://doi.org/10.1021/ol061320b