An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations
In Caenorhabdltls elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, "nonaging" dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations. © 2009 American Chemical Society.
Publication Source (Journal or Book title)
Butcher, R., Ragains, J., & Clardy, J. (2009). An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations. Organic Letters, 11 (14), 3100-3103. https://doi.org/10.1021/ol901011c