Title

An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations

Document Type

Article

Publication Date

7-16-2009

Abstract

In Caenorhabdltls elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, "nonaging" dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations. © 2009 American Chemical Society.

Publication Source (Journal or Book title)

Organic Letters

First Page

3100

Last Page

3103

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