Anti-HIV-1 activity of poly(mandelic acid) derivatives
Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMPDA. © 2007 American Chemical Society.
Publication Source (Journal or Book title)
Ward, M., Yu, B., Wyatt, V., Griffith, J., Craft, T., Neurath, A., Strick, N., Li, Y., Wertz, D., Pojman, J., & Lowe, A. (2007). Anti-HIV-1 activity of poly(mandelic acid) derivatives. Biomacromolecules, 8 (11), 3308-3316. https://doi.org/10.1021/bm070221y