Title

Aerosol Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

Document Type

Article

Publication Date

1-1-1994

Abstract

A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported. © 1994 American Society for Mass Spectrometry.

Publication Source (Journal or Book title)

Journal of the American Society for Mass Spectrometry

First Page

1

Last Page

9

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