Title

Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography/Time-of-Flight Mass Spectrometry

Document Type

Article

Publication Date

5-1-1994

Abstract

We report the application of aerosol matrix-assisted laser desorption ionization (MALDI) to liquid chromatography/ mass spectrometry (LC/MS). The aerosol MALDI experiment uses aerosol liquid introduction in conjunction with pulsed UV laser ionization to form ions from large biomolecules in solution. Mass analysis is achieved in a time-of-flight mass spectrometer. In the LC/MALDI-MS experiment, the matrix solution is combined with the column effluent in a mixing tee. LC/MALDI-MS is demonstrated for the separation of brady kinin, gramicidin S, and myoglobin. © 1994, American Chemical Society. All rights reserved.

Publication Source (Journal or Book title)

Analytical Chemistry

First Page

1601

Last Page

1609

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