Continuous flow infrared matrix-assisted laser desorption/ionization with a solvent matrix
Continuous flow matrix-assisted laser desorption/ionization (MALDI) was demonstrated with infrared laser desorption and an ethanol matrix. A capillary was used to deliver an analyte solution dissolved in ethanol to a metal frit embedded in a sample stage. Typical flow rates were 1.7μL/min. An optical parametric oscillator tuned to 2.8μm was used for desorption and ionization, and mass analysis was achieved with a 1 m linear time-of-flight mass spectrometer. Flow injection studies were performed with low picomolar quantities of insulin and myoglobin in solutions containing 0.1 to 1.0% glycerol in ethanol. © 2000 John Wiley and Sons, Ltd.
Publication Source (Journal or Book title)
Rapid Communications in Mass Spectrometry
Lawson, S., & Murray, K. (2000). Continuous flow infrared matrix-assisted laser desorption/ionization with a solvent matrix. Rapid Communications in Mass Spectrometry, 14 (3), 129-134. https://doi.org/10.1002/(SICI)1097-0231(20000215)14:3<129::AID-RCM849>3.0.CO;2-P