Title

Continuous flow infrared matrix-assisted laser desorption/ionization with a solvent matrix

Document Type

Article

Publication Date

2-15-2000

Abstract

Continuous flow matrix-assisted laser desorption/ionization (MALDI) was demonstrated with infrared laser desorption and an ethanol matrix. A capillary was used to deliver an analyte solution dissolved in ethanol to a metal frit embedded in a sample stage. Typical flow rates were 1.7μL/min. An optical parametric oscillator tuned to 2.8μm was used for desorption and ionization, and mass analysis was achieved with a 1 m linear time-of-flight mass spectrometer. Flow injection studies were performed with low picomolar quantities of insulin and myoglobin in solutions containing 0.1 to 1.0% glycerol in ethanol. © 2000 John Wiley and Sons, Ltd.

Publication Source (Journal or Book title)

Rapid Communications in Mass Spectrometry

First Page

129

Last Page

134

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