On-line single droplet deposition for MALDI mass spectrometry
A single droplet generator was coupled with a rotating ball inlet matrix-assisted laser desorption/ionization (MALDI) time of flight (TOF) mass spectrometer. Single droplets with 100 picoliter volume were ejected by a piezoelectric-actuated droplet generator and deposited onto a matrix-coated rotating stainless steel ball at atmospheric pressure. The single droplet deposit was transported to the vacuum side of the instrument where ionization was accomplished using a UV pulsed laser. Using this on-line interface, it was possible to obtain protonated molecule signal from as little as 10 fmol analyte. © 2004 American Society for Mass Spectrometry.
Publication Source (Journal or Book title)
Journal of the American Society for Mass Spectrometry
Zhang, X., Narcisse, D., & Murray, K. (2004). On-line single droplet deposition for MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry, 15 (10), 1471-1477. https://doi.org/10.1016/j.jasms.2004.06.016