Title

Smaller is better for antibiotic discovery

Document Type

Article

Publication Date

6-19-2009

Abstract

A recent study demonstrates the use of fragment-based drug discovery and virtual screening to develop inhibitors of biotin carboxylase that exhibit antibacterial activity. The work not only further validates biotin carboxylase as a target for antibiotic research but also provides a framework for using fragment-based drug discovery in antibiotic development.

Publication Source (Journal or Book title)

ACS chemical biology

First Page

397

Last Page

9

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