A Role for Exercise to Counter Skeletal Muscle Clock Disruption
Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock and reverting substrate metabolism back toward an optimal substrate balance.
Publication Source (Journal or Book title)
Exercise and sport sciences reviews
Erickson, M. L., Esser, K. A., Kraus, W. E., Buford, T. W., & Redman, L. M. (2021). A Role for Exercise to Counter Skeletal Muscle Clock Disruption. Exercise and sport sciences reviews, 49 (1), 35-41. https://doi.org/10.1249/JES.0000000000000235