Title

Overview: structural biology of integrins

Document Type

Article

Publication Date

1-1-2012

Abstract

Integrins are cell adhesion molecules that play important roles in many biological processes including hemostasis, immune responses, development, and cancer. Their adhesiveness is dynamically regulated through a process termed inside-out signaling. In addition, ligand binding transduces outside-in signals from the extracellular domain to the cytoplasm. Advances in the past several years have shed light on structural basis for integrin regulation and signaling, especially how the large-scale reorientations of the ectodomain are related to the inter-domain and intra-domain shape shifting that changes ligand-binding affinity. Experiments have also shown how the conformational changes of the ectodomain are linked to changes in the α- and β-subunit transmembrane and cytoplasmic domains.

Publication Source (Journal or Book title)

Methods in molecular biology (Clifton, N.J.)

First Page

81

Last Page

99

This document is currently not available here.

Share

COinS