Lysosomes are acidic, membrane-bound organelles that play essential roles in cellular quality control, metabolism, and signaling. The lysosomes of a cell are commonly depicted as vesicular organelles. Yet, lysosomes in fact show a high degree of ultrastructural heterogeneity. In some biological contexts, lysosome membranes naturally transform into tubular, non-vesicular morphologies. Though the purpose and regulation of tubular lysosomes has been historically understudied, emerging evidence suggests that tubular lysosomes may carry out unique activities, both degradative and non-degradative, that are critical to cell behavior, function, and viability. Here, we discuss recent advances in understanding the biological significance of tubular lysosomes in cellular physiology, and we highlight a growing number of examples that indicate the centrality of this special class of lysosomes to health and disease.
Publication Source (Journal or Book title)
Frontiers In Cell And Developmental Biology
Bohnert, K. A., & Johnson, A. E. (2022). Branching Off: New Insight Into Lysosomes As Tubular Organelles. Frontiers In Cell And Developmental Biology, 10 https://doi.org/10.3389/fcell.2022.863922