Document Type

Article

Publication Date

11-1-2015

Abstract

© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Ni-based precatalysts for the Suzuki-Miyaura reaction have potential chemical and economic advantages compared to commonly used Pd systems. Here, we compare Ni precatalysts for the Suzuki-Miyaura reaction supported by the dppf ligand in 3 oxidation states, 0, I and II. Surprisingly, at 80 °C they give similar catalytic activity, with all systems generating significant amounts of NiI during the reaction. At room temperature a readily accessible bench-stable NiII precatalyst is highly active and can couple synthetically important heterocyclic substrates. Our work conclusively establishes that NiI species are relevant in reactions typically proposed to involve exclusively Ni0 and NiII complexes.

Publication Source (Journal or Book title)

Angewandte Chemie - International Edition

First Page

13352

Last Page

13356

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