Title

The Chlamydomonas genome reveals the evolution of key animal and plant functions

Authors

Sabeeha S. Merchant, University of California, Los Angeles
Simon E. Prochnik, United States Department of Energy
Olivier Vallon, Institut de Biologie Physico-Chimique
Elizabeth H. Harris, Duke University
Steven J. Karpowicz, University of California, Los Angeles
George B. Witman, University of Massachusetts Medical School
Astrid Terry, United States Department of Energy
Asaf Salamov, United States Department of Energy
Lillian K. Fritz-Laylin, University of California, Berkeley
Laurence Maréchal-Drouard, Duke University
Wallace F. Marshall, University of California, San Francisco
Liang Hu Qu, Sun Yat-Sen University
David R. Nelson, University of Tennessee Health Science Center
Anton A. Sanderfoot, University of Minnesota Twin Cities
Martin H. Spalding, Iowa State University
Vladimir V. Kapitonov, Genetic Information Research Institute
Qinghu Ren, J. Craig Venter Institute
Patrick Ferris, Salk Institute for Biological Studies
Erika Lindquist, United States Department of Energy
Harris Shapiro, United States Department of Energy
Susan M. Lucas, United States Department of Energy
Jane Grimwood, Stanford University School of Medicine
Jeremy Schmutz, Stanford University School of Medicine
Igor V. Grigoriev, United States Department of Energy
Daniel S. Rokhsar, United States Department of Energy
Arthur R. Grossman, Carnegie Institution of Washington
Pierre Cardol, Institut de Biologie Physico-Chimique
Heriberto Cerutti, School of Biological Sciences
Guillaume Chanfreau, University of California, Los Angeles
Chun Long Chen, Sun Yat-Sen University
Valérie Cognat, CNRS Centre National de la Recherche Scientifique
Martin T. Croft, University of Cambridge
Rachel Dent, Department of Plant & Microbial Biology

Document Type

Article

Publication Date

10-12-2007

Abstract

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

Publication Source (Journal or Book title)

Science

First Page

245

Last Page

251

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