Spectroscopic and structural study of flobufen
Flobufen, 4-(2′,4′-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoicacid, and its 3-methyl isomer have been obtained by the Friedel-Crafts reaction of 2,4-difluorobiphenyl with itaconic or citraconic anhydride, respectively, followed by hydrogenation of the products. The structures of both compounds have been elucidated by mass spectrometry and 1H, 13C and 19F NMR spectroscopy. The structure of flobufen has been confirmed by a single-crystal X-ray study. © 1995 Elsevier Science S.A. All rights reserved.
Publication Source (Journal or Book title)
Journal of Fluorine Chemistry
Jegorov, A., Sedmera, P., Havlíček, V., Hušák, M., Pakhomova, S., Kratochvíl, B., Kuchař, M., & Bulej, P. (1995). Spectroscopic and structural study of flobufen. Journal of Fluorine Chemistry, 73 (2), 213-219. https://doi.org/10.1016/0022-1139(94)03220-T