Title
The structure of ergot alkaloid hydroxyergotamine
Document Type
Article
Publication Date
12-1-1996
Abstract
The structure of natural alkaloid hydroxyergotamine (P212121, a = 11.242(1) Å, b = 13.006(2) Å, c = 22.208(2) Å, Z = 4) has been solved by direct methods and refined anisotropically to the R value of 0.041. It has been established that the absolute stereochemistry classifies the alkaloid among the members of d-lysergic acid series. Ergolene moiety possesses the usual flap down conformation of the D ring. The piperazine ring F is in envelope form with the benzyl substituent in the eclipsed conformation. The L-proline ring has a predominant envelope form. The observed extended conformation of LSD-amide bond is stabilized by N3-NH3 ... O1 and O5-HO5 ... O1 intramolecular hydrogen bonds.
Publication Source (Journal or Book title)
Zeitschrift fur Kristallographie
First Page
39
Last Page
42
Recommended Citation
Pakhomova, S., Ondráček, J., Kratochvíl, B., Jegorov, A., & Cvak, L. (1996). The structure of ergot alkaloid hydroxyergotamine. Zeitschrift fur Kristallographie, 211 (1), 39-42. Retrieved from https://digitalcommons.lsu.edu/biosci_pubs/2869