Conformation of ergopeptam and ergopeptine alkaloids (ergocristam and ergocristine)
The crystal structures of two ergot alkaloids ergocristam (I) and ergocristine acetone solvate (II), have been determined by X-ray diffraction and compared with their conformation in solution obtained from NMR data. The presence of D-proline in I essentially influences the conformation of the alkaloid tripeptide moiety which seems likely to explain why I does not undergo further enzymatical hydroxylation and is found as a terminal step of ergot alkaloid biosynthesis.
Publication Source (Journal or Book title)
Zeitschrift fur Kristallographie
Pakhomova, S., Ondráček, J., Hušák, M., Kratochvíl, B., Jegorov, A., Cvak, L., Sedmera, P., & Havlíček, V. (1997). Conformation of ergopeptam and ergopeptine alkaloids (ergocristam and ergocristine). Zeitschrift fur Kristallographie, 212 (8), 593-600. Retrieved from https://digitalcommons.lsu.edu/biosci_pubs/2863