Title

Conformation of ergopeptam and ergopeptine alkaloids (ergocristam and ergocristine)

Document Type

Article

Publication Date

12-1-1997

Abstract

The crystal structures of two ergot alkaloids ergocristam (I) and ergocristine acetone solvate (II), have been determined by X-ray diffraction and compared with their conformation in solution obtained from NMR data. The presence of D-proline in I essentially influences the conformation of the alkaloid tripeptide moiety which seems likely to explain why I does not undergo further enzymatical hydroxylation and is found as a terminal step of ergot alkaloid biosynthesis.

Publication Source (Journal or Book title)

Zeitschrift fur Kristallographie

First Page

593

Last Page

600

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