Synthesis and crystal structure determination of cyclosporin H
Acid-catalyzed degradation of cyclosporin A was studied in various solvents and products of reaction were monitored by HPLC. Identification of amino acids and their chirality were determined after hydrolysis and derivatization by GC-MS. Cyclosporin H was isolated as the principal product and its structure was determined by X-ray diffraction: Cyclosporin H-diethyl ether-water (1 : 0.5 : 1) crystallizes in the monoclinic space group 12 with a = 12.338(2) Å, b = 18.963(2) Å, c = 34.074(3) Å, β = 96.47(2)°, Z = 4, and V = 7 921.4(17) Å3.
Publication Source (Journal or Book title)
Collection of Czechoslovak Chemical Communications
Jegorov, A., Cvak, L., Husek, A., Šimek, P., Heydová, A., Ondráček, J., Pakhomova, S., Hušák, M., Kratochvíl, B., Sedmera, P., & Havlíček, V. (2000). Synthesis and crystal structure determination of cyclosporin H. Collection of Czechoslovak Chemical Communications, 65 (8), 1317-1328. https://doi.org/10.1135/cccc20001317