Title

Synthesis and crystal structure determination of cyclosporin H

Document Type

Article

Publication Date

1-1-2000

Abstract

Acid-catalyzed degradation of cyclosporin A was studied in various solvents and products of reaction were monitored by HPLC. Identification of amino acids and their chirality were determined after hydrolysis and derivatization by GC-MS. Cyclosporin H was isolated as the principal product and its structure was determined by X-ray diffraction: Cyclosporin H-diethyl ether-water (1 : 0.5 : 1) crystallizes in the monoclinic space group 12 with a = 12.338(2) Å, b = 18.963(2) Å, c = 34.074(3) Å, β = 96.47(2)°, Z = 4, and V = 7 921.4(17) Å3.

Publication Source (Journal or Book title)

Collection of Czechoslovak Chemical Communications

First Page

1317

Last Page

1328

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