Title

Cyclosporins of symmetry P21 - A series of clathrates

Document Type

Article

Publication Date

1-1-2000

Abstract

A series of isomorphous clathrates (cyclosporin A: solvent = 1 : 1) is reported. The structure of the tetrahydrofuran (1) and dibutylether (2) clathrates have been determined by X-ray single crystal diffraction. The cyclosporin molecules in both structures are associated via van der Waals interactions forming cavities occupied by solvent molecules. The structure refinement based on room-temperature data sets show significant disorder of the side chains of the cyclosporin A molecule with no adequate model of the solvent molecule in both structures. In contrast, the position of dibutylether was successfully localised using a low-temperature data set for 2.

Publication Source (Journal or Book title)

Journal of Inclusion Phenomena

First Page

137

Last Page

153

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