Cyclosporins of symmetry P21 - A series of clathrates
A series of isomorphous clathrates (cyclosporin A: solvent = 1 : 1) is reported. The structure of the tetrahydrofuran (1) and dibutylether (2) clathrates have been determined by X-ray single crystal diffraction. The cyclosporin molecules in both structures are associated via van der Waals interactions forming cavities occupied by solvent molecules. The structure refinement based on room-temperature data sets show significant disorder of the side chains of the cyclosporin A molecule with no adequate model of the solvent molecule in both structures. In contrast, the position of dibutylether was successfully localised using a low-temperature data set for 2.
Publication Source (Journal or Book title)
Journal of Inclusion Phenomena
Jegorov, A., Pakhomova, S., Hušák, M., Kratochvíl, B., Žák, Z., Cvak, L., & Buchta, M. (2000). Cyclosporins of symmetry P21 - A series of clathrates. Journal of Inclusion Phenomena, 37 (1-4), 137-153. https://doi.org/10.1023/a:1008115029334