Title

New Pt(II) complexes with n-donor ligands: Potential use as chemotherapeutic agents

Document Type

Conference Proceeding

Publication Date

1-1-2015

Abstract

New complexes of the types, trans-Pt(DMSO)(L)Cl2 and trans- Pt(L)2Cl2 (L = 4-piperidinopyridine (4-(CH2)5Npy), pyppzSO2CH3, and pyppzSO2(3,5-Me2C6H3), were prepared by treating cis- [Pt(DMSO)2Cl2] with L in 1:1 or 1:2 (M:L) molar ratios, respectively. 1H NMR spectroscopic and single-crystal X-ray crystallographic analysis established that the pyridyl ring N is bound to the Pt(II) metal center in all complexes. The molecular structures of all complexes indicate that the Pt(II) ion has a square planar geometry with two trans chloro ligands. The other two positions are occupied by an Sbonded dimethyl sulfoxide and L ligands in the trans- PtII(DMSO)(L)Cl2 complexes and by two L ligands in trans-PtII(L)2Cl2 complexes. These new complexes have structural features similar to that of complexes with known chemotherapeutic properties and thus should be evaluated for anticancer potential.

Publication Source (Journal or Book title)

39th International Precious Metals Conference: Charting Precious Metals through the Changing Currents of Compliance, Finance, Consumer Trends, Risk and New Technology, IPMI 2015

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