Concerning the structure of 7α,15β-dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of cholesterol biosynthesis
Treatment of 3β-p-bromobenzoyloxy-14α, 15α-epoxy-5α-cholest-7-ene with gaseous HCI in chloroform at -25°C gave 3β-p-bromobenzoyloxy-7α, 15β-dichloro-5α-cholest-8(14)-ene in 93% yield. The structure of the latter compound was unequivocally established by the results of X-ray crystallographic analysis. © 1980.
Publication Source (Journal or Book title)
Chemistry and Physics of Lipids
Newcomer, M., Gilliland, G., Parish, E., Schroepper, G., & Quiocho, F. (1980). Concerning the structure of 7α,15β-dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of cholesterol biosynthesis. Chemistry and Physics of Lipids, 26 (3), 249-258. https://doi.org/10.1016/0009-3084(80)90055-9