Concerning the structure of 7α,15β-dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of cholesterol biosynthesis
Abstract
Treatment of 3β-p-bromobenzoyloxy-14α, 15α-epoxy-5α-cholest-7-ene with gaseous HCI in chloroform at -25°C gave 3β-p-bromobenzoyloxy-7α, 15β-dichloro-5α-cholest-8(14)-ene in 93% yield. The structure of the latter compound was unequivocally established by the results of X-ray crystallographic analysis. © 1980.
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