Title
Structural changes in retinol binding protein induced by retinol removal. A molecular dynamics study
Document Type
Article
Publication Date
9-16-1986
Abstract
Relationships between structure and function for retinol binding protein (RBP) are elucidated with help of a 2.0 Å resolution X-ray structure of the holo-protein and an average molecular dynamics (MD structure of the apo-form. Comparisons between MD simulations of bot the apo- and holo-forms with the X-ray holo-structure show conformational changes in apo-RBP that may be functionally significant. The average three dimensional structure obtained for apo-RBP is compared to the related protein apo-β-lactoglobulin. Available biochemical information is consistent with structure/function relationships derived here. © 1986 Academic Press, Inc.
Publication Source (Journal or Book title)
Biochemical and Biophysical Research Communications
First Page
564
Last Page
570
Recommended Citation
Sandblom, P., Åqvist, J., Jones, T., Newcomer, M., van Gunsteren, W., & Tapia, O. (1986). Structural changes in retinol binding protein induced by retinol removal. A molecular dynamics study. Biochemical and Biophysical Research Communications, 139 (2), 564-570. https://doi.org/10.1016/S0006-291X(86)80028-6