Title

The SH3 domain of Eps8 exists as a novel intertwined dimer

Document Type

Article

Publication Date

9-22-1997

Abstract

SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.

Publication Source (Journal or Book title)

Nature Structural Biology

First Page

739

Last Page

743

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