Protein polymerization via 3D domain swapping has been suggested to promote amyloid plaque formation. Two recent papers provide support for a role for domain swapping in the formation of highly ordered aggregates such as the fibrils characteristic of amyloid plaques.
Publication Source (Journal or Book title)
Nature Structural Biology
Newcomer, M. (2001). Trading places. Nature Structural Biology, 8 (4), 282-284. https://doi.org/10.1038/86134