Title

Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides

Document Type

Article

Publication Date

7-1-2013

Abstract

The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI = 26 nM) competitive inhibitor of sEH. From this observation, we found that alkyl-sulfoxides represent a new kind of pharmacophore for the inhibition of sEH. © 2013 Elsevier Ltd. All rights reserved.

Publication Source (Journal or Book title)

Bioorganic and Medicinal Chemistry Letters

First Page

3818

Last Page

3821

This document is currently not available here.

Share

COinS