Document Type
Article
Publication Date
7-1-2013
Abstract
The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI = 26 nM) competitive inhibitor of sEH. From this observation, we found that alkyl-sulfoxides represent a new kind of pharmacophore for the inhibition of sEH. © 2013 Elsevier Ltd. All rights reserved.
Publication Source (Journal or Book title)
Bioorganic and Medicinal Chemistry Letters
First Page
3818
Last Page
3821
Recommended Citation
Morisseau, C., Pakhomova, S., Hwang, S., Newcomer, M., & Hammock, B. (2013). Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorganic and Medicinal Chemistry Letters, 23 (13), 3818-3821. https://doi.org/10.1016/j.bmcl.2013.04.083