© 2019 Newcomer. On the fiftieth anniversary of the discovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variation on the textbook classic is described: An incomplete catalytic triad in a hydrolase is rescued by a chloride ion (Fig. 1). Structural and functional data provide compelling evidence that the active site of a phospholipase from Vibrio vulnificus employs the anion in place of the commonly observed Asp, reminding us that even well-trodden scientific ground has surprises in store.
Publication Source (Journal or Book title)
Journal of Biological Chemistry
Newcomer, M. (2019). Chloride to the rescue. Journal of Biological Chemistry, 294 (30), 11402-11403. https://doi.org/10.1074/jbc.H119.009687