Comprehensive analysis of a large genomic sequence at the putative B-cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus
In many haematological diseases, and more particularly in B-cell chronic lymphocytic leukaemia (B-CLL), the existence of a tumour suppressor gene located within the frequently deleted region 13q14.3, has been put forward. A wide candidate region spanning from marker D13S273 to D13S25 has been proposed and an extensive physical map has been constructed by several teams. In this study, we sequenced a minimal core deleted region that we have previously defined and annotated it with flanking available public sequences. Our analysis shows that this region is gene-poor. Furthermore, our work allowed us to identify new alternative transcripts, spanning core regions, of the previously defined candidate genes DLEU1 and DLEU2. Since their putative involvement in B-CLL was controversial, our present study provide support for reconsidering the DLEU1 and DLEU2 genes as B-CLL candidate genes, with a new definition of their organisation and context. © 2001 Elsevier Science B.V. All rights reserved.
Publication Source (Journal or Book title)
Mutation Research - Mutation Research Genomics
Rondeau, G., Moreau, I., Bézieau, S., Petit, J., Heilig, R., Fernandez, S., Pennarun, E., Myers, J., Batzer, M., Moisan, J., & Devilder, M. (2001). Comprehensive analysis of a large genomic sequence at the putative B-cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus. Mutation Research - Mutation Research Genomics, 458 (3-4), 55-70. https://doi.org/10.1016/S0027-5107(01)00219-6